Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia (EVOS)

Clinical Research Centre, Malaysia

Status and phase: Enrolling; Phase 3

Conditions: Staphylococcus Aureus Bacteremia

Treatments: Drug: IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline; Drug: Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid

Study type: Interventional

Funder types: Other

Identifiers

NCT06336824

EVOS 1.3 dated 12 March 2024

Details and patient eligibility

About

The Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus aureus Bacteraemia (EVOS) study is a multicentre, randomized, open-label, parallel group, phase 3, non-inferiority trial of early intravenous to oral antibiotic switch in comparison with standard intravenous antibiotic regime among patients with uncomplicated Staphylococcus aureus bacteraemia (SAB). The study is based on the hypothesis that an early switch from IV to oral antimicrobial therapy is non-inferior and safe compared to conventional minimum 14-day course of IV therapy in patients with low-risk uncomplicated SAB.

Full description

The study is conducted at 12 government tertiary hospitals with infectious diseases physicians in Malaysia. The study population comprises of 290 patients with uncomplicated SAB who have received 3 to 7 days of definitive IV antimicrobial therapy. Eligible participants are randomized 1:1 into 2 groups, early oral antibiotic switch versus standard IV antibiotic therapy, following the inclusion and exclusion criteria.

The study consists of 3 stages for each patient with a duration of approximately 12 weeks: screening and enrolment, open-label treatment with 7 to 11 days of study antibiotics, and follow-up until day 90 post-randomization. Phone call or inpatient follow up will be conducted at Day 7-11, Day 30, and Day 90 post- randomization to review patient's condition.

Enrollment: 290 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Blood culture positive for Staphylococcus aureus (S. aureus).

2. Received 3 to 7 days of definitive IV antimicrobial therapy, defined as:

   • Cloxacillin or cefazolin for methicillin-sensitive staphylococcus aureus (MSSA); Vancomycin or ceftaroline for methicillin-resistant staphylococcus aureus (MRSA).
   • Proven in-vitro susceptibility and adequate dosing given (as determined by the principal investigator).

3. Achieved clearance of bacteraemia, defined as at least one documented latest negative follow-up blood culture obtained within 72 hours after the initiation of definitive IV antimicrobial therapy.

4. Achieved defervescence, defined as sustained body temperature ≤37.5°C within 48 hours before randomization.

5. Able to provide written informed consent to participate trial.

Exclusion criteria

1. Evidence of metastatic infection of S. aureus: for example, infective endocarditis, intraabdominal abscess, lung empyema, and osteomyelitis. Radiological investigations such as chest X-ray, ultrasound, echocardiogram, and CT scan are not mandatory prior to enrolment, but should be done at the discretion of the treating physician if clinically indicated.

2. Septic shock, defined as hypotension requiring vasopressors to maintain MAP ≥65 mmHg despite adequate volume resuscitation.

3. Received more than 5 days of non-study antibiotics as empirical therapy prior to enrolment.

4. Polymicrobial bloodstream infection, defined as isolation of pathogens other than S. aureus from a blood culture obtained prior to randomization. Common skin contaminants such as coagulase-negative staphylococci, Bacillus spp., and diphtheroid will not be considered to represent polymicrobial infection.

5. Known history of S. aureus infection within the past 3 months.

6. Inability to tolerate oral therapy or poor absorption of oral medications, or not suitable for ongoing IV therapy (for example, difficult intravenous access)

7. No options of oral antibiotic available for patient due to:

   • In vitro resistance of S. aureus to all oral study drugs.
   • Known contraindications to receive the active oral study drugs. For example, hypersensitivity reaction to trimethoprim-sulfamethoxazole, thrombocytopenia secondary to linezolid etc.
   • Non-availability of oral study drugs at the study sites.

8. Patient is concomitantly receiving oral antibiotics which are active against S. aureus. For example, trimethoprim-sulfamethoxazole for Pneumocystis jirovecii pneumonia prophylaxis.

9. Presence of a non-removable foreign body such as prosthetic heart valve, vascular graft, pacemaker, automated implantable cardioverter-defibrillator, ventriculoperitoneal shunt, prosthetic joint, and fracture fixation implant

10. Failure or inability to remove intravascular catheter that is present when first positive blood culture was drawn.

11. Known comorbidity that increased the risk of complicated infections:

    • End-stage renal disease

    • Severe liver disease (Child-Pugh class C)

    • Severe immunodeficiency:

      • HIV-positive patients with CD4<200 cells/uL or AIDS
      • primary immunodeficiency disorders
      • high-dose steroid therapy (>1 mg/kg prednisone or equivalent doses given for > 4 weeks or planned during intervention)
      • immunosuppressive therapy
      • neutropenia (<500 neutrophils/μl) at randomization or neutropenia expected during intervention phase due to immunosuppressive treatment
      • solid organ or hematopoietic stem cell transplantation within the past 6 months or planned during treatment period

13.Short life expectancy < 3 months

14.Pregnancy (for women of childbearing potential)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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290 participants in 2 patient groups

Early Oral Switch Therapy (EOS)

Experimental group

Description:

Patients will switch from IV therapy to oral antibiotics for 7 to 11 days to achieve a total 14 days of definitive antimicrobial therapy for SAB. First choice oral antibiotics for MSSA and MRSA: Tab. Trimethoprim-sulfamethoxazole (TMP 10mg/kg/day) Alternative oral antibiotics for MSSA: Tab. Clindamycin 600mg TDS, Tab. Cephalexin 1gm QID, Tab Linezolid 600mg BD Alternative oral antibiotics for MRSA: Tab. Linezolid 600mg BD

Treatment:

Drug: Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid

Standard IV therapy (SIV)

Active Comparator group

Description:

Patients will continue with IV therapy for 7 to 11 days to achieve a total 14 days of definitive antimicrobial therapy for SAB. First choice IV antibiotics for MSSA: IV Cloxacillin 2g every 4 or 6 hours Alternative IV antibiotics for MSSA: IV Cefazolin 2g TDS First choice IV antibiotics for MRSA: IV Vancomycin 15-20mg/kg BD Alternative IV antibiotics for MRSA: IV Ceftaroline 600mg TDS

Treatment:

Drug: IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline