Early Mechanical Ventilation for Guillain Barré Syndrome

University of Versailles

Status and phase: Completed; Phase 2

Conditions: Acute Respiratory Failure; Guillain Barré Syndrome

Treatments: Procedure: physiotherapy and oxygen if needed; Procedure: mechanical ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00167622

P050103

PS050103

Details and patient eligibility

About

The purpose of this study is to determine whether early mechanical ventilation can prevent hospital acquired pneumonia in adults with Guillain Barré Syndrome.

Full description

Hospital acquired pneumonia is a common and severe complication of Guillain Barré Syndrome. Several factors have been recognized as predictors of respiratory failure in adults with Guillain Barré Syndrome. They include a time from disease onset and patient admission of less seven days, inability to lift head, impaired swallowing and a forced vital capacity of less than 60% of predictive value. We reasonned that early mechanical ventilation may prevent aspiration which is likely the main cause of pneumonia in these patients.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Guillain Barré Syndrome
• Age of 18 years old or more
• Inability to lift head
• Time from onset of motor deficit less than 7 days
• Written informed consent

Exclusion criteria

• Glasgow coma score of less than 8
• Unstable hemodynamic status
• Current pneumonia
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

1

Active Comparator group

Description:

Physiotherapy, oxygen as needed

Treatment:

Procedure: physiotherapy and oxygen if needed

2

Experimental group

Description:

Mechanical ventilation

Treatment:

Procedure: mechanical ventilation