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Early MRI Detection of Myocardial Deterioration as a Preventive, Disease Staging, and Prognostic Biomarker in Insulin Resistance

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Stanford University

Status

Completed

Conditions

Diabetes
Insulin Resistance
Non-ischemic Cardiomyopathy
Cardiomyopathies
Cardiac Fibrosis

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of this study is to evaluate the relationship between insulin resistance (IR) and myocardial tissue abnormalities. The study will focus on a patient population, South Asians, with a high prevalence of IR.

Full description

Cardiac fibrosis has been linked to adverse outcomes in non-ischemic cardiomyopathy. Fibrosis is also detectable in diabetic patients, but does not appear to closely track with insulin sensitivity. Hence, fibrosis may be an independent risk factor for adverse outcomes in IR and diabetic patients. As a result, a critical need exists to develop a non-invasive tool to identify and treat the highest-risk patients. Early detection of cardiac fibrosis and other CMR- detectable abnormalities in IR patients may help to 'stage' a patient's disease process and future risk of events, ultimately leading to an adjustment in the aggressiveness of their medical management and long-term monitoring accordingly. This project is aimed at reducing the mortality and morbidity associated with insulin resistance and diabetes, and the investigators believe this project could have a transformative impact on long-term diabetic care and shed new light upon the biology of diffuse cardiac fibrosis in insulin resistance and diabetes and its role in shaping the long-term cardiovascular risk for these patients.

Enrollment

39 patients

Sex

All

Ages

20 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • South Asian

Exclusion criteria

  • Pregnant women
  • Patients with prior diagnoses of diabetes
  • Patients on insulin therapy
  • Patients with known coronary heart disease or other non-ischemic cardiomyopathies

Trial design

39 participants in 2 patient groups

South Asians with Insulin Resistance
Description:
125 patients (anticipated)
South Asians without Insulin Resistance
Description:
125 patients (anticipated)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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