Early NCPAP Before Surfactant Treatment in Very Preterm Infants With RDS

Central South University

Status: Completed

Conditions: Preterm Infants,; Nasal Continuous Positive Airway Pressure,; Respiratory Distress Syndrome,; Bronchopulmonary Dysplasia; Surfactant Treatment,

Study type: Observational

Funder types: Other

Identifiers

NCT01996670

huohuiyi20131121

huo20131121 (Registry Identifier)

Details and patient eligibility

About

We hypothesis a period of early NCPAP before surfactant treatment is effective for treating RDS and preventing BPD in very premature infants.

Enrollment: 683 patients

Sex: All

Ages: 30 minutes to 2 hours old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All enrolled infants were able to breathe at 5 min of age, had evidence of respiratory distress, unable to receive surfactant therapy, and were administrated with early NCPAP as the initial treatment

Exclusion criteria

• Exclusion criteria were endotracheal intubation for resuscitation or insufficient respiratory drive, died in the first 24 hours after birth, known genetic disorders, potentially life-threatening conditions unrelated to prematurity, and premature rupture of membranes (PROM) for >3 weeks.

Trial design

683 participants in 3 patient groups

<2h group

2-4h group

>4h group