Early Neurological Deterioration in Patients With Acute Ischemic Stroke (ENDAIS)

N

Nanjing Medical University

Status

Unknown

Conditions

Cerebral Infarction

Study type

Observational

Funder types

Other

Identifiers

NCT03703986
2014-SR-099

Details and patient eligibility

About

This study set out to explore the risk factors of early neurological deterioration (END) occurred in patients with acute ischemic stroke and to investigate the corresponding predictors.

Full description

END refers to the illness aggravation occurred in the early stage of stroke and often indicates a poor outcome. Some clinical scales may play an important role in its diagnoses and treatments. Across the reviewed studies, the risk factors of END, which included biochemical parameters, neuroimaging, ect. were explored incompletely and the effective predictors of END is unknown. We aimed to explore the risk factors of END and investigate the predictive value of certain scales.

Enrollment

1,200 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Subjects with acute ischemic stroke
  • Subjects with detailed progress notes

Exclusion criteria

  • Subjects with thrombolysis therapy
  • Subjects with transient ischemia attach
  • Subjects complicated with seriously underlying diseases

Trial design

1,200 participants in 2 patient groups

END group
Description:
The patients in this group had an elevation of ≥ 2 points in the National Institute of Health Stroke Scale (NIHSS) within 7 days of stroke onset.
non-END group
Description:
The patients in this group had a slight increase of < 2 points or a decrease in NIHSS within 7 days of stroke onset.

Trial contacts and locations

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Central trial contact

Hong Cheng, MD; Mei Sun, MD

Data sourced from clinicaltrials.gov

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