Early Neurovascular Adaptations in Aging Women

University of Missouri (MU)

Status and phase: Enrolling; Early Phase 1

Conditions: Aging; Sympathetic Nervous System; Blood Flow; Women

Treatments: Drug: Estrogen; Drug: Acetylcholine; Drug: Norepinephrine; Drug: Isoproterenol; Drug: Nitroprusside

Study type: Interventional

Funder types: Other

Identifiers

NCT06520982

2109189

Details and patient eligibility

About

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Enrollment: 64 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Assigned female at birth (AFAB)
• 18-70 years of age

Exclusion criteria

• Assigned male at birth (AMAB)
• Pregnancy, breastfeeding
• Body mass index ≥30 kg/m2
• Taking medications known to affect metabolic, autonomic, and/or respiratory function
• Oral hormonal contraception in last 6 month
• History of hormone replacement therapy
• History of hyster- or oophor-ectomy
• Current smoking/Nicotine use
• Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
• Chronic disease
• Blood pressure ≥140/90 mmHg
• Communication barriers

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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64 participants in 1 patient group

Women

Other group

Description:

Women will be 18-70 years of age

Treatment:

Drug: Nitroprusside

Drug: Isoproterenol

Drug: Norepinephrine

Drug: Acetylcholine

Drug: Estrogen