Early Non Invasive Ventilation in Immuno-compromized Patients With Acute Respiratory Failure. (IVNICTUS)

Assistance Publique - Hôpitaux de Paris

Status

Completed

Conditions

Adult

Acute Respiratory Failure Admitted in ICU

Immuno Compromized

Treatments

Procedure: Oxygen therapy only

Procedure: Early non invasive ventilation

Study type

Interventional

Funder types

Other

Identifiers

NCT01915719

IVNICTUS

Details and patient eligibility

About

Assess the superiority of early non invasive ventilation in comparison to Oxygen therapy only, for immuno-compromized patients with acute respiratory failure

Enrollment

374 patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age over 18 years old
ICU admission
Acute respiratory failure defined by (PaO2<60 mmHg at room air) or (polypnea >30/min or dyspnea at rest) or respiratory distress. Since less than 72 hours.
Immuno compromized patient defined by solid tumor (treated since less than 5 years) or haematological malignancy (treated since less than 5 years) or Solid organ transplantation or Stem cell transplantation or Immunosuppressive treatment (steroid > 1mg/kg/d or >1 month or other immunosuppressive treatment >1 month)

Exclusion criteria

Hypercapnia >50 mmHg or increased of hypercapnia >10 mmHg under Oxygen treatment
Need of immediate mechanical ventilation
Obvious cardiogenic oedema
Vasopressor use >0.03 µg/kg/min
Glasgow Score <13
End of life decision
Acute myocardial infarction
Patient refusal
Pregnancy
No national health insurance