Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism

Vanderbilt University Medical Center

Status

Completed

Conditions

Pseudohypoparathyroidism

Albright Hereditary Osteodystrophy

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT02411461

VR7195

1K23DK101689-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a. The investigators will compare their results to those of healthy siblings and other obese children.

Full description

Pseudohypoparathyroidism type 1a (PHP1a) is a genetic disorder that causes early-onset, syndromic obesity and cognitive impairment. This study aims to evaluate eating behaviors, cognition and executive function in children with PHP1a, compared with healthy siblings and matched obese controls.

Enrollment

39 patients

Sex

All

Ages

6 to 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control

Exclusion Criteria (PHP1a):

Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months
Type 2 diabetes

Exclusion Criteria (Controls):

Obesity due to a genetic syndrome, growth hormone deficiency, untreated hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration
Weight loss greater than 10% over the previous 6 months
Autism or other significant learning disorder
Type 2 diabetes
Other significant medical condition