Early Outcomes of Radical Debridement Versus no Debridement Under Different Surgical Procedures

The Second Hospital of Anhui Medical University

Status: Completed

Conditions: Spinal Tuberculosis

Treatments: Procedure: no debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT02638272

1898

Details and patient eligibility

About

Whether radical debridement is necessary for the treatment of thoracic and lumbar tuberculosis is still questionable. The objective of this prospective randomized study was to compare the outcomes of radical debridement versus no debridement under different surgical procedures for the treatment of thoracic and lumbar tuberculosis.

Full description

Seventy-four thoracic and lumbar tuberculosis patients with a neurological function of grade D and E underwent surgeries from January 2009 to January 2014. All patients were divided into group A and group B by taking the drawing of lots. In group A, radical debridement, bone graft and instrumentation were performed. In group B, isolated posterior instrumentation without debridement were performed in all cases and drainage of iliopsoas abscess via laparoscopy in 2 cases. The operative time, blood loss, visual analogue score (VAS), erythrocyte sedimentation rate (ESR), kyphotic angle, Frankel grading, fusion rate and complications were evaluated.

Enrollment: 74 patients

Sex: All

Ages: 14 to 67 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Frankel grading was grade D and E
2. Severe back pain
3. Abscess combined with high pressure symptoms
4. Larger sequestrum formation or sinus
5. Significant spinal instability.

Exclusion criteria

1. Frankel grading was grade A,B and C
2. Conservative treatment

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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74 participants in 1 patient group

spine surgery

Other group

Description:

The objective was to compare the outcomes of radical debridement versus no debridement under different surgical procedures for the treatment of thoracic and lumbar tuberculosis.

Treatment:

Procedure: no debridement