Early Passive Verticalization in Critically Ill Patients (TILT)

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Unknown

Conditions: Critical Illness

Treatments: Other: Rest in bed; Other: Passive verticalization

Study type: Interventional

Funder types: Other

Identifiers

NCT02270762

Early passive verticalization

Details and patient eligibility

About

In the critically patient bed rest and inmovilization are some of the responsable of the development of respiratory complications. Early physical exercise is a tool to prevent respiratory complications as lost of respiratory muscle strength, decrease in functional residual capacity and hypoxemia improving oxygenation. In some cases critically ill conditions implies use of pharmacological sedation. That condition limit the active physical exercise. However, some technicals aids as Tilt table allows execution of passive early movilization.

The aim of this study is to assess the effect of early passive verticalization assisted by tilt table on alveolar recruitment and pulmonary ventilation in intensive care unit (ICU) patients, evaluated with electrical impedance tomography (EIT) ICU patients included at day of evaluation will be evaluated consecutively with EIT in three stages; 1) in the supine position (at 30° of inclination), 2) verticalized in tilt table (at 60º of inclination) 3) in the supine position (at 30° of inclination)

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient admitted at the Intensive Care Medical/Sirurgical Unite of Clinic Saint Luc
• Days of hospitalization between 1 and 10
• Hemodynamically stable
• Patient or family member sign the informed consent
• Sedated patients

Exclusion criteria

• With risk of evisceration
• Therapy withdrawal
• With cardiac devices (Pace Maker)
• Persistent cough
• Patches or open wounds in zone of electrodes
• Presence of high vasopressor medication (noradrenaline > 3 mg/h)
• PEEP > 15 cm H2
• Acute Myocardial Infarction
• Active bleeding
• Intracranial pressure > 20 mm Hg or with major inestability

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 3 patient groups

1) Rest in bed

Experimental group

Description:

First evaluation of EIT with patient in bed at 30º of head inclination during 5 minutes.

Treatment:

Other: Rest in bed

Other: Rest in bed

2) Passive Verticalization

Experimental group

Description:

Second evaluation of EIT with patient in tilt table at 60º of verticalization during 10 minutes.

Treatment:

Other: Passive verticalization

3) Rest in bed

Experimental group

Description:

Last evaluation of EIT with patient in bed at 30º of head inclination during 20 minutes.

Treatment:

Other: Rest in bed

Other: Rest in bed