Early Prevention Strategies of Severe Proliferative Vitreoretinopathy Base on Precision Diagnosis of Single Cell Sequencingvitreoretinopathy

Tongji University

Status: Unknown

Conditions: Rhegmatogenous Retinal Detachment

Treatments: Diagnostic Test: RPE cell collection and single cell heterogeneity study; Procedure: Conventional Surgery for Retinal Detachment; Procedure: Postoperative intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT04520789

09.01.10002

Details and patient eligibility

About

Study of initiating proliferative vitreoretinopathy (PVR)cell subtype (PVR initiating cells (PVR-IC) in RPE cells of rhegmatogenous retinal detachment (RRD) patients; to prove the percentage of PVR-IC decides the risk of serious PVR occurring after surgery; to investigate the safety and efficacy of early local steroids drug intervention in patients with severe postoperative PVR.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) Age: 18-60 years old, regardless of gender; (2) Clinical diagnosis of with rhegmatogenic retinal detachment (RRD); (3) Surgery for Retinal Detachment is required; (4) Myopia < = 800 degrees; (4) PVR classification: no restrictions; (5) Patients undergoing the first or second operation. (6) Patients volunteered to participate in this study and signed informed consent.

Exclusion criteria

• (1) Exudative detachment of retina; (2) Those who are allergic to the drugs used in the study; (3) Combined with other eye diseases: other fundus diseases, glaucoma, corneal opacity diseases, genetic diseases); (4) history of internal eye surgery >=3 times; (5) Postoperative follow-up could not be scheduled; (6) Patients with systemic diseases (such as asthma, heart failure, myocardial infarction, liver failure, kidney failure and other major diseases).

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

RD control group

Sham Comparator group

Description:

Conventional Surgery for Retinal Detachment

Treatment:

Procedure: Conventional Surgery for Retinal Detachment

RD treatment group1

Experimental group

Description:

Conventional Surgery for Retinal Detachment，RPE cell collection, single cell heterogeneity study

Treatment:

Procedure: Conventional Surgery for Retinal Detachment

Diagnostic Test: RPE cell collection and single cell heterogeneity study

RD treatment group2

Active Comparator group

Description:

Conventional Surgery for Retinal Detachment，RPE cell collection, single cell heterogeneity study, postoperative intervention

Treatment:

Procedure: Postoperative intervention

Procedure: Conventional Surgery for Retinal Detachment

Diagnostic Test: RPE cell collection and single cell heterogeneity study