Early Prevention Strategies of Severe Proliferative Vitreoretinopathy Base on Precision Diagnosis of Single Cell Sequencingvitreoretinopathy

T

Tongji University

Status

Unknown

Conditions

Rhegmatogenous Retinal Detachment

Treatments

Diagnostic Test: RPE cell collection and single cell heterogeneity study
Procedure: Conventional Surgery for Retinal Detachment
Procedure: Postoperative intervention

Study type

Interventional

Funder types

Other

Identifiers

NCT04520789
09.01.10002

Details and patient eligibility

About

Study of initiating proliferative vitreoretinopathy (PVR)cell subtype (PVR initiating cells (PVR-IC) in RPE cells of rhegmatogenous retinal detachment (RRD) patients; to prove the percentage of PVR-IC decides the risk of serious PVR occurring after surgery; to investigate the safety and efficacy of early local steroids drug intervention in patients with severe postoperative PVR.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) Age: 18-60 years old, regardless of gender; (2) Clinical diagnosis of with rhegmatogenic retinal detachment (RRD); (3) Surgery for Retinal Detachment is required; (4) Myopia < = 800 degrees; (4) PVR classification: no restrictions; (5) Patients undergoing the first or second operation. (6) Patients volunteered to participate in this study and signed informed consent.

Exclusion criteria

(1) Exudative detachment of retina; (2) Those who are allergic to the drugs used in the study; (3) Combined with other eye diseases: other fundus diseases, glaucoma, corneal opacity diseases, genetic diseases); (4) history of internal eye surgery >=3 times; (5) Postoperative follow-up could not be scheduled; (6) Patients with systemic diseases (such as asthma, heart failure, myocardial infarction, liver failure, kidney failure and other major diseases).

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

60 participants in 3 patient groups

RD control group
Sham Comparator group
Description:
Conventional Surgery for Retinal Detachment
Treatment:
Procedure: Conventional Surgery for Retinal Detachment
RD treatment group1
Experimental group
Description:
Conventional Surgery for Retinal Detachment,RPE cell collection, single cell heterogeneity study
Treatment:
Procedure: Conventional Surgery for Retinal Detachment
Diagnostic Test: RPE cell collection and single cell heterogeneity study
RD treatment group2
Active Comparator group
Description:
Conventional Surgery for Retinal Detachment,RPE cell collection, single cell heterogeneity study, postoperative intervention
Treatment:
Procedure: Postoperative intervention
Procedure: Conventional Surgery for Retinal Detachment
Diagnostic Test: RPE cell collection and single cell heterogeneity study

Trial contacts and locations

0

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Central trial contact

Fang Wang, MD,phD; Conghui Zhang, MD,phD

Data sourced from clinicaltrials.gov

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