Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients

Domonkos Trásy

Status: Completed

Conditions: Bacterial Infections

Study type: Observational

Funder types: Other

Identifiers

NCT02294695

EProK study

Details and patient eligibility

About

To investigate the value of procalcitonin (PCT) kinetics between 0-8-16-24 hours after starting empirical antibiotic therapy in critically ill patients, to predict appropriate or inappropriate antibiotic treatment.

Enrollment: 209 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical signs of infection
• Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
• Suspected site of infection has to be present and documented
• Microbiological sample sent for staining
• Inflammatory markers available at the start of the therapy

Exclusion criteria

• Patients younger than 18 years
• Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
• Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
• Following cardiopulmonary resuscitation
• End stage diseases with a "do not resuscitate" order
• Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
• Post cardiac surgery patients

Trial design

209 participants in 2 patient groups

Appropriate empiric antibiotic therapy

Description:

Based on the microbiological results patients were grouped post hoc into "appropriate" and "inappropriate" groups by two independent experts (intensivist, infectologist) who were blinded for PCT.

Inappropriate empiric antibiotic therapy

Description:

Based on the microbiological results patients were grouped post hoc into "appropriate" and "inappropriate" groups by two independent experts (intensivist, infectologist) who were blinded for PCT.