Early Renal Replacement Therapy and the Outcome of Acute Kidney Injury (EarlyRRT)

Chulalongkorn University

Status: Completed

Conditions: Acute Renal Failure

Treatments: Procedure: continuous renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01819038

chula

Details and patient eligibility

About

This research project is a prospective study to compare mortality between early renal replacement therapy (RRT) and late renal replacement therapy by using plasma neutrophil gelatinase associated lipocalin (pNGAL) as a tool in decision- making.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must have given his/her informed and signed consent
• patients with acute kidney injury in the intensive care ward.

Exclusion criteria

• The patient refuses to sign the consent
• The patient is pregnant, parturient, or breastfeeding
• End stage renal disease
• Chronic renal failure
• previous kidney transplant

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 3 patient groups

High NGAL and early RRT

Experimental group

Description:

NGAL level \> 400 ng/ml and start continuous renal replacement therapy early

Treatment:

Procedure: continuous renal replacement therapy

High NGAL and late RRT

Experimental group

Description:

NGAL \> 400 ng/ml and start continuous renal replacement therapy late

Treatment:

Procedure: continuous renal replacement therapy

Low NGAL

Active Comparator group

Description:

NGAL \< 400 ng/ml and starting continuous renal replacement therapy follow with absolute indication

Treatment:

Procedure: continuous renal replacement therapy