Status and phase
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About
The study intends to evaluate the efficacy of early rhBNP on myocardial work in patients with anterior ST-segment elevation myocardial infarction after percutaneous coronary intervention
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Inclusion criteria
Anterior myocardial infarct (anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within 12 hours after onsets of symptom;
No contraindication for rhBNP;
Left anterior descending (LAD) as culprit vessel, with TIMI 0-1 grade.
Exclusion criteria
1.Cardiogenic shock (systolic BP <90mmHg after fluid infusion or systolic BP<100mmHg after vasoactive drugs);
3.Severe arrhythmia: with III degree A-V block ,atrial fibrillation,ventricular fibrillation,ventricular tachycardia;
Any history of severe renal or hepatic dysfunction (hepatic failure, cirrhosis, portal hypertension or active hepatitis); neutropenia or thrombocytopenia; known acute pancreatitis;
Pregnant or lactating;
life expectancy≤12 months;
Inability to follow the protocol and comply with follow-up requirements or any other reason the investigator feels would place the patient at increased risk;
Primary purpose
Allocation
Interventional model
Masking
200 participants in 2 patient groups, including a placebo group
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Central trial contact
Song Ding, MD,Ph.D.
Data sourced from clinicaltrials.gov
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