Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement

University of Alberta

Status: Completed

Conditions: Chronic Rhinosinusitis

Treatments: Other: Routine Irrigation; Other: Early saline irrigation

Study type: Interventional

Funder types: Other

Identifiers

NCT01943370

Pro00042764 (Other Identifier)

ESESS-001

Details and patient eligibility

About

Nasal saline is a common treatment adjunct in the post-operative setting for endoscopic sinus surgery. However, the ideal timing and quantity of irrigation in the early post-operative period remains unknown. Proposed benefits of early, large volume irrigation include removal and softening of crusts, resulting in improved mucociliary clearance. The potential benefit of early large volume saline irrigation on post-operative day three to ease or reduce the need for early post-operative debridement has not been studied.

Enrollment: 25 patients

Sex: All

Ages: 17+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Diagnosis of CRS with or without polyposis
• Undergoing bilateral endoscopic sinus surgery
• Availability of pre-operative CT paranasal sinuses

Exclusion criteria

Patients with diagnosis of:

• Primary ciliary dyskinesia
• Immunodeficiency
• Cystic fibrosis

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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25 participants in 2 patient groups

Early saline irrigation

Experimental group

Description:

Initiation of early saline irrigation

Treatment:

Other: Early saline irrigation

Late or Routine Saline Irrigation

Active Comparator group

Description:

Routine initiation of saline irrigation

Treatment:

Other: Early saline irrigation

Other: Routine Irrigation