Transjugular Intrahepatic Portosystemic Shunts Improve Survival in Patients With Cirrhosis and Recurrent Ascites (TIPS)

Tang-Du Hospital

Status: Completed

Conditions: Refractory Ascites

Treatments: Procedure: transjugular intrahepatic portal shunt

Study type: Observational

Funder types: Other

Identifiers

NCT06196723

Xijing Hospital

Details and patient eligibility

About

Currently, there is limited evidence regarding the survival benefit of early transjugular intrahepatic portal shunt (TIPS) placement in patients with cirrhosis and recurrent ascites. This observational study aimed to assess whether early TIPS improves the survival of patients with advanced cirrhosis and recurrent ascites. We will compare large volume paracenteses plus albumin (LVP+A） to see if TIPS improves the survival of patients with advanced cirrhosis and recurrent ascites.

Enrollment: 462 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Definite diagnosis of recurrent ascites in cirrhosis (based on clinical symptoms, laboratory and imaging studies, or liver biopsy) TIPS or LVP+A therapy, -

Exclusion criteria

Malignant neoplasm, including hepatocellular carcinoma with extrahepatic metastasis Prior liver transplantation Severe heart and lung dysfunction Recurrent hepatic encephalopathy Concomitant active infection TIPS with the use of uncovered stents Complete portal vein thrombosis

Trial design

462 participants in 2 patient groups

TIPS

Description:

transjugular intrahepatic portal shunt

Treatment:

Procedure: transjugular intrahepatic portal shunt

LVP+A

Description:

large volume paracenteses plus albumin