Early Tracheotomy for Switching Between Invasive and Noninvasive Ventilation to Facilitate Weaning

Chongqing Medical University

Status: Unknown

Conditions: Ventilator Weaning

Treatments: Procedure: switching between invasive and noninvasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02921334

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Details and patient eligibility

About

The aim of this study is early tracheotomy to facilitate weaning by switching between invasive and noninvasive ventilation.

Full description

When a patient is eligible to this study, he or she is randomly assigned to intervention or control group.In intervention group,tracheotomy is performed. And then, patient is switched to noninvasive ventilation by masking the tracheotomy tube. If the patient presents distress in noninvasive ventilation, he or she is switched to invasive ventilation. If the distress relieves, patient is switched to noninvasive ventilation again until the patient successfully weans from ventilator. In control group, the patient is weaned as the conventional methods.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• duration of invasive ventilation 5 to 7 days
• anticipation of difficult weaning
• Glasgow Coma Scale ≥13
• no upper airway obstruction
• presence of spontaneous breath

Exclusion criteria

• age less than 18 or more than 85 years;
• contraindications for noninvasive ventilation;
• anticipation of survival less than 6 months;
• refusal of tracheotomy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Intervention group

Experimental group

Description:

Patients in this group are received ventilator weaning by switching between invasive and noninvasive ventilation.

Treatment:

Procedure: switching between invasive and noninvasive ventilation

Control group

No Intervention group

Description:

Patients in this group are weaned from ventilator as conventional methods.