Early Variations in Immune Aging (EVIA-NL)

Radboud University Medical Center

Status: Terminated

Conditions: Aging; Aging Well; Immuno Aging

Treatments: Other: No intervention, we just study 'aging'

Study type: Observational

Funder types: Other

Identifiers

NCT06295354

2024-17062

Details and patient eligibility

About

Background:

Despite an increase in lifespan over the last decades, our healthspan lags behind. In our aging population, it is pressing that we prevent age-related morbidities and associated burden on the health care system. Instead of investigating aging in already aged populations, the currently proposed study aims to elucidate the process of immune aging in relation to biological aging, demographic and lifestyle factors in young and midlife adults, and to identify early biomarkers and pathways associated with fast versus slow immune aging and aging endotypes.

Study design:

A single-center, observational prospective cohort study in the Netherlands. Participants from priorly established cohorts will be invited to join the EVIA-study. We will obtain demographic and basic clinical data and biological samples (blood and stool) at baseline and after three years, with a short, yearly online questionnaire in between.

Enrollment: 1,000 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Aged between 20 and 60 years;
• Able to communicate orally in Dutch or English;
• Able to give informed consent.

Exclusion criteria

• Any systemic disease or condition, or the use of systemic medication, with the exception of the following:

  • Cardiovascular disease and related medication
  • Metabolic syndrome, including diabetes, hypertension, and hyperuricemia

• Pregnancy at inclusion (will be recorded during study);

• Acute illness or fever <1 month before inclusion;

• Received vaccines or antibiotics 3 months before inclusion;

• Participation in an intervention trial;

• Legally incapacitated or unwilling to provide informed consent.

Trial design

1,000 participants in 4 patient groups

20-30 years old

Description:

The target population consists of 1000 participants, equally distributed over different age groups (20-30, 30-40, 40-50, and 50-60 years old) and sex. Main exclusion criteria are any systemic condition or medication apart from cardiometabolic disorders, pregnancy at inclusion or recent vaccinations. Individuals will be compared over time, and age groups will be compared over time and per time point. None of the age groups will get an intervention, the goal is to observationally study them.

Treatment:

Other: No intervention, we just study 'aging'

3-40 years old

Description:

The target population consists of 1000 participants, equally distributed over different age groups (20-30, 30-40, 40-50, and 50-60 years old) and sex. Main exclusion criteria are any systemic condition or medication apart from cardiometabolic disorders, pregnancy at inclusion or recent vaccinations. Individuals will be compared over time, and age groups will be compared over time and per time point. None of the age groups will get an intervention, the goal is to observationally study them.

Treatment:

Other: No intervention, we just study 'aging'

40-50 years old

Description:

The target population consists of 1000 participants, equally distributed over different age groups (20-30, 30-40, 40-50, and 50-60 years old) and sex. Main exclusion criteria are any systemic condition or medication apart from cardiometabolic disorders, pregnancy at inclusion or recent vaccinations. Individuals will be compared over time, and age groups will be compared over time and per time point. None of the age groups will get an intervention, the goal is to observationally study them.

Treatment:

Other: No intervention, we just study 'aging'

50-60 years old

Description:

The target population consists of 1000 participants, equally distributed over different age groups (20-30, 30-40, 40-50, and 50-60 years old) and sex. Main exclusion criteria are any systemic condition or medication apart from cardiometabolic disorders, pregnancy at inclusion or recent vaccinations. Individuals will be compared over time, and age groups will be compared over time and per time point. None of the age groups will get an intervention, the goal is to observationally study them.

Treatment:

Other: No intervention, we just study 'aging'