Early Vascular Ageing in the YOUth (EVA4YOU)

VASCage

Status: Completed

Conditions: Cardiovascular Pathology; Vascular Stiffness; Obesity; Cardiovascular Diseases; Vascular Diseases; Atherosclerosis; Headache; Hypertension; Overweight; Sleep Disorder; Life Style; Cardiovascular Risk Factor; Sleep; Non-Alcoholic Fatty Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT04598685

EVA4YOU

Details and patient eligibility

About

This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the aorta and on the Pulse-Wave Velocity.

A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Full description

EVA4YOU is a cross-sectional study enrolling 3000 students and apprentices aged between 14 and 19 years. Examinations are conducted at schools and companies throughout Tyrol, Austria and include laboratory measurements; standardized medical interviews; anthropometry; liver elastography; ultrasonography of the carotid artery and the aorta, and blood pressure, bioelectrical impedance; visceral abdominal fat-tissue-thickness measurement, pulse-wave velocity measurements.

The study hypothesis is that the cardiovascular risk factors measured already influence the formation of atherosclerosis (measured as carotid and aortic Intima-Media Thickness and Pulse-Wave-Velocity) in adolescents.

A long-term follow-up by means of record linkage is furthermore planned to evaluate the effect of early atherosclerosis and the cardiovascular risk profile on future morbidity with a special focus cardio- and cerebrovascular events.

Enrollment: 1,517 patients

Sex: All

Ages: 14 to 19 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adolescents at the age of 14 to 19 years
• Signed informed consent of subjects (and legal guardian if subject < 18 years of age)

Exclusion criteria

• Persons, who are suspended upon a court order or upon other legal processes or are accommodated according to the Hospitalization Act, or for whom a custodian is appointed (or appointment is initiated).
• Persons with impaired power of judgment
• Persons who are currently engaged in military or community service