Early Versus Late Parenteral Nutrition in the Pediatric Intensive Care Unit (PEPaNIC)

Catholic University (KU) of Leuven

Status

Active, not recruiting

Conditions

Critical Illness

Children

Treatments

Other: Late parenteral nutrition

Study type

Interventional

Funder types

Other

Identifiers

NCT01536275

2012-000811-10 (EudraCT Number)

NL38772.000.12 (Other Identifier)

ML8052 (Other Identifier)

PEPaNIC

IWT-TBM 110685 (Other Grant/Funding Number)

Details and patient eligibility

About

In the PEPaNIC trial it is investigated whether withholding parenteral nutrition during the first week in critically ill children is beneficial, compared to the current standard of the early start of parenteral nutrition.

Enrollment

1,440 patients

Sex

All

Ages

Under 17 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients admitted to the PICU with a STRONGkids score of 2 points or more upon ICU admission

Exclusion criteria

Age of 17 years or older
Patients with a DNR code at the time of ICU admission.
Patients expected to die within 12 hours (=moribund patients).
Patient readmitted to ICU after randomization to the PEPaNIC trial, more than 48 hours after the initial discharge
Patients transferred from another paediatric intensive care after a stay of more than 7 days
Patients suffering from ketoacidotic or hyperosmolar coma on admission.
Patients suffering from Short Bowel Syndrome on home PN or other conditions that require home PN
Patients suspicious or established inborn metabolic diseases requiring specific diet
STRONGkids score lower than 2 on ICU admission.
Premature Newborns ( 37 weeks gestational age upon admission in the PICU)
Prior inclusion in another randomized controlled outcome study