Early Versus Late Use of Hi-VNI in Covid-19

Assiut University

Status: Completed

Conditions: COVID-19

Study type: Observational

Funder types: Other

Identifiers

NCT05663138

Hi-VNI in covid 19 patients

Details and patient eligibility

About

This study evaluate early administration of high-velocity nasal insufflation in COVID-19 patients presented with acute respiratory failure after failure of conventional low flow nasal cannula bypassing the escalating step of Non re-breathing mask where early use of High velocity nasal insufflations achieved better improvement of respiratory distress, lower oxygen requirements and shorter ICU stay.

Full description

The study included 30 COVID-19 patients admitted to intensive care of COVID-19 zone, chest Department, quarantine section, Assiut University hospital. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real time PCR for SAR-COV-2 RNA assay on 7500 Applied Bio-system. All patients received treatment based on the protocol of Egyptian Ministry of Health, Patients enrolled in the study were categorized into 2 groups, the 1st group included patients whom were shifted to Hi-VNI after failure of high flow nasal cannula, while the 2nd group included patients shifted to Hi-VNI after failure of non-rebreathing mask, using a Precision flow vapotherm (vapotherm, Inc, 100 Domain device Exeter, NH 03833, T: 603-658-0011, USA), that provide high velocity humidified flow through narrow bore nasl prongs

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1-severe COVID Patients with hypoxemic respiratory failure. 2- Patients with no comorbidities

Exclusion criteria

1. Non severe COVID Patients
2. Patients with comorbidities (e.g chronic chest dis, DM, renal failure and hepatic failure
3. Patients indicated for mechanical ventilation
4. Patients with marked hypercapnia in need for non-invasive ventilation

Trial design

30 participants in 2 patient groups

Early Hi-VNI

Description:

Group 1 of early shift to Hi-VNI after nasal cannula

Late Hi-VNI

Description:

Group 2 of late use of Hi-VNI after NRM