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Eating Behaviors Among Weight-Discordant Siblings

University of Pennsylvania logo

University of Pennsylvania

Status

Completed

Conditions

Obesity

Treatments

Other: Feeding study

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT01598389
K01DK078601

Details and patient eligibility

About

The purpose of this study was to compare weight-discordant siblings in eating in the absence of hunger, caloric compensation, and the quality of their habitual diet. The investigator hypothesized that, within families and controlling for age differences, overweight and obese siblings would show greater eating in the absence of hunger, poorer caloric compensation, and poorer diet quality (e.g., increased percent of energy from fat and caloric beverages) compared to normal-weight siblings.

Full description

The study used a discordant sibling design to compare putative obesity-promoting eating traits among siblings, 5-12 years, who were raised in the same household, but were discordant for weight status (normal-weight: BMI-for-age between 5 and less than the 85th percentile; overweight/obese: BMI-for-age greater or equal to the 85th percentile). Forty-seven pairs of same-sex siblings (boys and girls) were recruited from the greater Philadelphia area to participate in a 4-week study during which their eating behaviors and body composition were assessed. The study tested the hypotheses that overweight/obese, compared to normal-weight, siblings exhibit 1) a weaker ability to compensate for calories, 2) a greater susceptibility towards eating in the absence of hunger, and 3) habitual dietary intakes that favor increased dietary energy density (kcal/g) and increased %energy derived from fat and caloric beverages. The use of a behavioral genetics design to study eating phenotypes among siblings is a unique approach to elucidate shared and non-shared environmental influences that can contribute to variations in weight status during childhood.

Enrollment

94 patients

Sex

All

Ages

5 to 12 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • same-sex;
  • weight discordant (normal-weight vs. overweight/obese);
  • meet age criteria;
  • like most foods that were served in the study.

Exclusion criteria

  • serious medical conditions or medication use known to affect appetite, food intake and body weight;
  • developmental or psychiatric conditions;
  • food allergies or nutrient intolerances (including lactose intolerance).

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

94 participants in 3 patient groups

Low energy-dense preload
Experimental group
Treatment:
Other: Feeding study
High energy-dense preload
Experimental group
Treatment:
Other: Feeding study
No preload
Experimental group
Treatment:
Other: Feeding study

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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