Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients (GREFFE)

University Hospital Center (CHU) Dijon Bourgogne

Status: Completed

Conditions: Liver Transplant; Eating Behaviour

Treatments: Other: Respiratory quotient; Other: Olfactory liking

Study type: Interventional

Funder types: Other

Identifiers

NCT02859506

BRONDEL INRA 2013

Details and patient eligibility

About

Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis.

The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.

Enrollment: 73 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• persons who have provided written informed consent
• persons aged between 18 and 70 years
• persons waiting for a liver transplantation (group LT)
• persons with stable liver damage
• persons waiting for a kidney transplantation (KT)
• healthy subjects (control group) no known disease

Exclusion criteria

• persons without national health insurance cover
• persons with chronic infection,
• persons with acute infection,
• persons with progressive cancer,
• persons with an antibiotic treatment,
• persons who drink alcohol,
• pregnant or breast-feeding women,
• persons with an aversion to the foods proposed in the study,
• persons taking treatments known to interfere with gustatory and olfactory performance,
• adults under guardianship

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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73 participants in 4 patient groups, including a placebo group

liver transplant

Experimental group

Treatment:

Other: Olfactory liking

Other: Respiratory quotient

kidney transplant

Active Comparator group

Treatment:

Other: Olfactory liking

Other: Respiratory quotient

control

Placebo Comparator group

Treatment:

Other: Olfactory liking

Other: Respiratory quotient

stable liver damage

Active Comparator group

Treatment:

Other: Olfactory liking

Other: Respiratory quotient