Eating Disorders Genetics Initiative (EDGI)

University of North Carolina (UNC)

Status: Completed

Conditions: Binge-Eating Disorder; Bulimia Nervosa; Anorexia Nervosa

Treatments: Other: Eating disorder diagnosis group

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04378101

19-1378

R01MH120170 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The overarching intention of the Eating Disorder Genetics Initiative (EDGI) is to lay the foundation for all future genomic discovery in eating disorders--anorexia nervosa (AN), bulimia nervosa (BN), and binge-eating disorder (BED)--by exploring both genetic and behavioral factors. To do this, information will be collected from 4000 people who have provided DNA samples for the Anorexia Nervosa Genetics Initiative (ANGI) and the same information and DNA will be collected from an additional 16,000 people. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

Enrollment: 17,991 patients

Sex: All

Ages: 15 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, or no history of any disordered eating behavior
• Age 15-99 years

Exclusion criteria

• History of subthreshold disordered eating behaviors

Trial design

17,991 participants in 4 patient groups

Anorexia Nervosa Case

Description:

Participants in this group have a life-time history of anorexia nervosa as determined by an algorithm applied to their responses to an eating disorders screening questionnaire (ED100K) that is based on the Structured Clinical Interview for Axis 1 Disorders.

Treatment:

Other: Eating disorder diagnosis group

Bulimia Nervosa Case

Description:

Participants in this group have a life-time history of bulimia nervosa as determined by an algorithm applied to their responses to an eating disorders screening questionnaire (ED100K) that is based on the Structured Clinical Interview for Axis 1 Disorders. These participants do not have a history of anorexia nervosa.

Treatment:

Other: Eating disorder diagnosis group

Binge-Eating Disorder Case

Description:

Participants in this group have a life-time history of binge-eating disorder as determined by an algorithm applied to their responses to an eating disorders screening questionnaire (ED100K) that is based on the Structured Clinical Interview for Axis 1 Disorders. These participants do not have a history of anorexia nervosa or bulimia nervosa.

Treatment:

Other: Eating disorder diagnosis group

Control

Description:

Participants in this group have no history of disordered eating behaviors as determined by an algorithm applied to their responses to an eating disorders screening questionnaire (ED100K) that is based on the Structured Clinical Interview for Axis 1 Disorders.

Treatment:

Other: Eating disorder diagnosis group