Eating Disorders Genetics Initiative 2 (EDGI2)

University of North Carolina (UNC)

Status: Enrolling

Conditions: Avoidant Restrictive Food Intake Disorder; Binge-Eating Disorder; Bulimia Nervosa; Anorexia Nervosa

Treatments: Other: Eating disorder diagnosis group

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT06594913

23-2887

R01MH136156 (U.S. NIH Grant/Contract)

R01MH136149 (U.S. NIH Grant/Contract)

R01MH136157 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.

Enrollment: 20,000 estimated patients

Sex: All

Ages: 12 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms
• Age 12-99 years, depending on country. (US enrollment age is 18-99)

Exclusion criteria

• History of subthreshold disordered eating behaviors.

Trial design

20,000 participants in 5 patient groups

Anorexia nervosa

Description:

Individuals with a self-reported lifetime history of anorexia nervosa.

Treatment:

Other: Eating disorder diagnosis group

Bulimia nervosa

Description:

Individuals with a self-reported lifetime history of bulimia nervosa.

Treatment:

Other: Eating disorder diagnosis group

Binge-eating disorder

Description:

Individuals with a self-reported lifetime history of binge-eating disorder.

Treatment:

Other: Eating disorder diagnosis group

ARFID

Description:

Individuals with a self-reported lifetime history of avoidant restrictive food intake disorder.

Treatment:

Other: Eating disorder diagnosis group

Control

Description:

Individuals with no history of disordered eating behaviors or symptoms

Treatment:

Other: Eating disorder diagnosis group