Eating Phenotypes for Childhood Obesity in the Context of Familial Obesity Risk

University of Pennsylvania

Status: Completed

Conditions: Obesity

Treatments: Behavioral: % COMPX (low ED vs. high ED preload); Behavioral: EAH (low ED vs. high ED snacks)

Study type: Interventional

Funder types: Other

Identifiers

NCT02928874

820661

Details and patient eligibility

About

Using an integrated approach, this study examines multiple eating traits concurrently under states of hunger and satiety. It examines the impact of short-term appetite and intake regulation on longer-term energy intake control and weight development in a cohort of ethnically diverse normal-weight and obese boys and girls with different familial predispositions to obesity.

Enrollment: 212 patients

Sex: All

Ages: 7 to 9 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 7-9 years of age
• Normal-weight or overweight/obese who are at low risk or high risk for obesity based on maternal BMI
• Like most foods served during the study
• Be regular breakfast eaters

Exclusion criteria

• Have serious medical conditions known to affect food intake or body weight
• Have any developmental, medical, or psychiatric conditions that might impact study compliance
• Have a learning disability or poor reading ability/comprehension
• Have visual or auditory impairment
• Are taking medications associated with developmental, medical, or psychiatric disorders or medications known to affect appetite, food intake or body weight
• Are underweight
• Have food allergies related to the foods served in the study or are lactose intolerant
• Do not regularly eat breakfast
• Do not like or cannot eat foods served during experimental meal or are unable to finish compulsory preload
• Mothers who are pregnant

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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212 participants in 2 patient groups

Caloric compensation

Experimental group

Description:

Twenty-five minutes before breakfast, participants will be asked to consume in full one of two oatmeal preloads that will vary in ED. The order of preload conditions will be randomized across groups of children participating in the visits.

Treatment:

Behavioral: % COMPX (low ED vs. high ED preload)

Eating in the absence of hunger (EAH)

Experimental group

Description:

During both study visits, children's EAH will be assessed after lunch and again after dinner. The order of presenting the low and high ED snacks will be counterbalanced across meals.

Treatment:

Behavioral: EAH (low ED vs. high ED snacks)