EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

Rennes University Hospital

Status: Unknown

Conditions: Infection

Treatments: Other: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT02917486

35RC15_8901

Details and patient eligibility

About

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.

The exhibition is evaluated by population pharmacokinetic modeling.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age over 18 years
• Hospitalisation in intensive care
• Treatment with ECMO or without ECMO
• Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours
• With an arterial catheter
• Patient Information or their next of kin according to the patients status.

Exclusion criteria

• Pregnancy
• Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty

Trial design

60 participants in 2 patient groups

ECMO piperacillin

Description:

patients in intensive care treated with ECMO with antiinfective therapy : piperacillin

Treatment:

Other: blood sample

without ECMO piperacillin

Description:

patients in intensive care without ECMO with antiinfective therapy : piperacillin

Treatment:

Other: blood sample