Eccentric Cycling Exercise on Hemodynamic and Hemorheologic Properties

Chang Gung Medical Foundation

Status: Unknown

Conditions: Eccentric Exercise Training

Treatments: Behavioral: Concentric cycling training; Behavioral: Eccentric cycling training

Study type: Interventional

Funder types: Other

Identifiers

NCT04773444

201900415A3C

Details and patient eligibility

About

The effects of an eccentric endurance training on central and peripheral hemodynamic adaptations and erythrocyte rheology during maximal exercise remained to be unexplored. The current study examined the contribution of rheological functions and/or hemodynamic adaptation to changes in oxygen consumption (VO2) following the matched-power output eccentric (ECT) or concentric cycling training (CCT).

Method: A total of 39 sedentary males were randomly assigned into either CCT (n=13) or ECT (n=13) for 30 min a day, 5 days a week for 6 weeks at 60% of maximal workload or to a CTL (control group, n = 13). A graded exercise test (GXT) was performed before and after the intervention. Central and microvascular adaptations were evaluated using thoracic impedance and near-infrared spectroscopy (NIRS), respectively. Rheological characteristics was determined by an ektacytometer.

Full description

Endurance training is a well known strategy for improving fitness capacity. However, some populations are intolerance to complete the usual exercise training program, such as chronic heart or pulmonary disease or the elderly. Therefore, ECT is a candidate training strategy for those individuals.

Erythrocytes deformability is significantly related to the blood perfusion in microcirculation. The impaired erythrocyte-related rheology further lead to reduced aerobic capacity by our research team. Therefore, the lower energy consumed in ECT may avoid the oxidative stress. To now, less studies have demonstrated whether ECT influences peripheral hemodynamics by erythrocyte rheology and the blood flow from the central effect.

The investigators aimed to investigate the effects of CCT and ECT on oxygen consumption response explained by changes in local blood perfusion, blood cell rheology, or central function to attempt developing its application in rehabilitation.

Enrollment: 60 estimated patients

Sex: Male

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• in sedentary lifestyle, who were nonsmokers, nonusers of medications/vitamins, and free of any cardiopulmonary/hematological risks

Exclusion criteria

• regular exercise habits (i.e., exercise frequency once per week, duration >20 min).

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Eccentric cycling training

Experimental group

Description:

Moderate intensity cycling training in eccentric type

Treatment:

Behavioral: Eccentric cycling training

Concentric cycling training

Experimental group

Description:

Moderate intensity cycling training in concentric type (intensity matched the eccentric training)

Treatment:

Behavioral: Concentric cycling training

Control group

No Intervention group

Description:

without receiving any exercise training