Eccentric Exercise and Oxidative Stress

European University Cyprus

Status: Completed

Conditions: Aging; Muscle Damage; Oxidative Stress

Treatments: Other: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01728675

EUC-019 (Other Grant/Funding Number)

EUC-017

Details and patient eligibility

About

The purpose of the present investigation is to compare the responses and adaptations of young and elderly individuals to repeated eccentric exercise in regards to muscle function and redox homeostasis in a side-by-side comparison.

Full description

Despite the progress of analytic techniques and the refinement of study designs, striking disagreement exists among studies regarding the influence of exercise on muscle function and redox homeostasis in the elderly. A specific exercise protocol will be applied (the repeated eccentric model) to produce long-lasting and extensive changes in redox biomarkers and to examine more easily the potential effects of aging. Ten young men and ten elderly men will underwent an isokinetic eccentric exercise session, which will be repeated after three weeks. Muscle function indices and redox biomarkers will be assessed in urine, plasma or erythrocytes pre exercise, immediately post exercise, 2 and 4 days post exercise.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subject provides written informed consent
• physiological health profile
• stable at their anthropometric characteristics for at least the last year

Exclusion criteria

• muscle disease
• prior history of musculoskeletal injury to the lower limbs
• smokers
• consumed any nutritional supplement the last 3 months
• performed intense eccentric exercise the last 6 months
• non Caucasian

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Young group

Experimental group

Description:

Participants will underwent two isokinetic eccentric exercise sessions

Treatment:

Other: Exercise

Elderly group

Experimental group

Description:

Participants will underwent two isokinetic eccentric exercise sessions

Treatment:

Other: Exercise