Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

Utah State University

Status: Withdrawn

Conditions: Blood Flow Restriction

Treatments: Other: Exercise; Other: Eccentric plus blood-flow restriction

Study type: Interventional

Funder types: Other

Identifiers

NCT04977804

12042b

Details and patient eligibility

About

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Full description

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last ~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-30 years of age
• currently engaged in some form of resistance training between 1-3 times per week
• must have been training aerobically, but no more than 3 hours a week for the past six months

Exclusion criteria

• Must not have had any surgery of the lower limbs within the past 1 year period
• Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)
• < 76 inches tall (in order to fit on the training machine)
• Maximal strength of < 725 lbs for the eccentric training device
• If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.

For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Eccentric only training

Active Comparator group

Description:

This is the experimental control; where this group will be used as the standard active comparison condition.

Treatment:

Other: Exercise

Eccentric plus blood-flow restriction

Experimental group

Description:

This is the experimental condition involving the eccentric resistance training with blood flow restriction.

Treatment:

Other: Eccentric plus blood-flow restriction