Echocardiography Findings in Patients With Myocardial Fibrosis and Severe Aortic Stenosis (SAS-fibrosis)

Norwegian University of Science and Technology

Status: Completed

Conditions: Aortic Valve Stenosis; Myocardial Fibrosis

Treatments: Diagnostic Test: Transthoracic echocardiography; Diagnostic Test: Cardiac magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT07331116

2017/1068b

Details and patient eligibility

About

Patients with aortic stenosis waiting for aortic valve repair were investigated with echocardiography preoperatively, and a myocardial biospy was taken during the operation. We aim to perform a retrospective analysis of these data, to look for correlations between biopsy-verified myocardial fibrosis and echocardiography parameters.

The patients also had cardiac magnetic resonance imaging performed, for a non-invasive quantification of myocardial fibrosis.

Full description

The primary purpose of the study is to retrospectively compare echocardiography measurements with a myocardial biopsy taken perioperatively in patients with aortic stenosis requiring aortic valve replacement.

Echocardiography and endomyocardial biopsy have been performed in close proximity in time. Due to a small sample size and a large number of echocardiography measurements being possible, only a limited number of prespecified comparisons are performed.

Cardiac magnetic resonance (CMR) was also performed in patients without contraindication, providing a non-invasive gold standard for diffuse fibrosis and replacement fibrosis. A secondary goal will be to investigate how echocardiography parameters performs compared to CMR in quantifying myocardial fibrosis.

Enrollment: 22 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Planned for aortic valve replacement for symptomatic, severe aortic stenosis

Exclusion criteria

• Previous myocardial infarction / coronary disease that can cause fibrosis
• Do not wish to participate in study

Trial design

22 participants in 2 patient groups

Aortic stenosis with biopsy-verified myocardial fibrosis

Description:

Periopererative echocardiography

Treatment:

Diagnostic Test: Cardiac magnetic resonance imaging

Diagnostic Test: Transthoracic echocardiography

Aortic stenosis without biopsy-verified myocardial fibrosis

Description:

Periopererative echocardiography

Treatment:

Diagnostic Test: Cardiac magnetic resonance imaging

Diagnostic Test: Transthoracic echocardiography