Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

Mass General Brigham

Status: Completed

Conditions: Acromegaly

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01819883

2012P002517

Details and patient eligibility

About

This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.

Enrollment: 40 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18 - 75 yr (both groups)
• Study subjects with active acromegaly
• Healthy controls

Exclusion criteria

• Serum creatinine or alanine aminotransferase (ALT) > 2 times the upper limit of normal, metastatic cancer.
• Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
• Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
• Pregnant women

Trial design

40 participants in 2 patient groups

Active Acromegaly

Description:

All study subjects with acromegaly will be studied twice - once during the active stage of their disease (pre-treatment) and a second time: 3 months after treatment of acromegaly. Controls will be studied at one time point.

Healthy controls