Education on BDNF on Pain Levels

Universidad Autonoma de Madrid

Status: Enrolling

Conditions: Musculoskeletal Pain; Chronic Pain

Treatments: Behavioral: Pain Neuroscience Education; Behavioral: Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05623579

2022A36005

Details and patient eligibility

About

The promotion of neuroplasticity in conjunction with strategies for restructuring maladaptive cognitions that largely cause the activation of neural networks that contribute to the perpetuation of pain is therefore a fundamental neurophysiological principle for establishing a neurophysiological basis for pain.

perpetuation of pain, is therefore a fundamental neurophysiological principle for establishing physiotherapy therapeutic to establish therapeutic strategies from physiotherapy that contribute to improve the quality of life of patients with chronic pain. patients with chronic pain.

Based on the theory that neurotrophic factors such as BDNF play a fundamental role in the initiation and or maintenance of hyperexcitability of central neurons in pain, we consider that the levels of this neurotrophic factor, such as BDNF, may have an important role in the perpetuation of pain.

that the levels of this neurotrophic factor may be modified by the application of a therapeutic education protocol, favoring therapeutic education protocol, favoring a reduction in pain intensity.

Enrollment: 66 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• males and females aged 18 to 65 years with musculoskeletal pain for a minimum of 3 months
• patients recruited by information pamphlets from the university clinic of the Rey Juan Carlos University, and CSEU La Salle
• not having received physiotherapy treatment for this same process in the last 3 months.
• ability to perform all the clinical tests and to understand the study process, as well as to obtain informed consent.

Exclusion criteria

• Systemic, neurological, oncological or inflammatory diseases; psychiatric pathologies, pregnancy, type II diabetes.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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66 participants in 2 patient groups

Intervention

Experimental group

Description:

Pain Education plus Exercise

Treatment:

Behavioral: Pain Neuroscience Education

Behavioral: Exercise

Control

Active Comparator group

Description:

Exercise

Treatment:

Behavioral: Exercise