EEG Results of Deep TMS in Patients With OCD

Medipol Health Group

Status: Unknown

Conditions: Obsessive-Compulsive Disorder; EEG With Periodic Abnormalities

Treatments: Drug: Paroxetine; Device: Deep Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT05188833

EEG.DeepTMS.OCD

Details and patient eligibility

About

Obsessive Compulsive Disorder (OCD) is a psychiatric disorder in which involuntary thoughts and irresistible behaviors are seen and its prevalence affects 2%-3% of the general population. Deep TMS is a treatment method that provides stimulation of lower parts of the brain and larger brain volume, and in addition to drug treatment and psychotherapy approaches, magnetic stimulation of localized brain regions and disease symptoms are addressed. The presence of the medial prefrontal cortex and anterior cingulate cortex in the dysfunction on the specified cycle seen in OCD patients indicates that the stimulation of these regions is necessary for a meaningful result in the treatment of deep TMS; studies show that the effect of the deep TMS method emerges as a result of the stimulation of these regions. 30 patients with OCD will included into the study and dividen into 3 groups (DTMS (n=10), DTMS + Paroxetine (n=10), Control(n=10)). Patients will evaluated in terms of depression, quality of life, and EEG before and after the intervention.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Being diagnosed with Obsessive Compulsive Disorder within the framework of DSM-5 criteria

Exclusion criteria

• Not volunteering to comply with the research program
• Presence of a metal piece on the head
• Having a pacemaker inserted
• Having had a previous epileptic seizure

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Deep Transcranial Magnetic Stimulation

Active Comparator group

Description:

The treatment will be carried out for 6 weeks, 5 days a week, in total 30 sessions; 20 hz using Brainsway H-7 helmet. It will be applied to the mPFC and ACC simultaneously with a total of 2000 beats at a frequency of 50 beats in each string.

Treatment:

Device: Deep Transcranial Magnetic Stimulation

Deep Transcranial Magnetic Stimulation and Paroxetine

Experimental group

Description:

The treatment will be carried out for 6 weeks, 5 days a week, in total 30 sessions; 20 hz using Brainsway H-7 helmet. It will be applied to the mPFC and ACC simultaneously with a total of 2000 beats at a frequency of 50 beats in each string. In addtion to DTMMS, paroxetine will applied.

Treatment:

Drug: Paroxetine

Device: Deep Transcranial Magnetic Stimulation

Paroxetine

Active Comparator group

Description:

Paroxetine is a type of antidepressant known as an SSRI (selective serotonin reuptake inhibitor). It's often used to treat depression in OCD.

Treatment:

Drug: Paroxetine