EEG Studies of Induction and Recovery From Propofol Induced General Anesthesia

Mass General Brigham

Status: Completed

Conditions: Brain Activity Under Sedation

Treatments: Drug: Propofol

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01543633

5DP1OD003646 (U.S. NIH Grant/Contract)

2005P001549

Details and patient eligibility

About

The purpose of this study is to investigate how the commonly used anesthetic drug propofol works in the brain to produce loss of consciousness. While under general anesthesia your brain waves will be measured using electroencephalogram (EEG). On a separate day, the patient's brain will be imaged using magnetic resonance imaging (MRI).

Enrollment: 36 patients

Sex: All

Ages: 18 to 36 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, non-smoking male and female volunteers, ages 18-36 with normal body weight.
• American Society of Anesthesiologists (ASA) physical status I

Exclusion criteria

• History of head trauma
• Surgical aneurysm clips
• Cardiac pacemaker
• Prosthetic heart valve
• Neurostimulator
• Implanted pumps
• Cochlear implants
• Metal rods, plates
• Screws
• Intrauterine device
• Hearing aid
• Dentures (which might create NMR artifacts)
• Metal injury to eyes

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

36 participants in 1 patient group

Active Study Arm

Experimental group

Description:

Subjects recruited into this study will be required to undergo a base MRI scan of the brain. On a separate day propofol will be administered with concurrent EEG while subjects respond to stimuli.

Treatment:

Drug: Propofol