EEG Studies of Ketamine General Anesthesia

Mass General Brigham

Status and phase

Completed

Phase 3

Phase 2

Conditions

Anesthesia

Treatments

Drug: Ketamine

Study type

Interventional

Funder types

Other

Identifiers

NCT03553758

2018P000417

Details and patient eligibility

About

We are doing this research study to find out how and where ketamine acts in the brain. Ketamine is an anesthetic (a drug or agent used to decrease or eliminate the feeling of pain by putting you in an unconscious state). We will look at the brain using a machine that records the brain's electrical activity, called an electroencephalogram (EEG). We will assess how it impacts patient's pain responses.

Full description

In this trial, participants will be given ketamine at a high enough dosage to induce general anesthesia. EEG recording will be conducted during this time. Cognitive assessments and pain monitoring will be administered at various points before and after ketamine induction.

Enrollment

16 patients

Sex

All

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Between the ages of 18 to 45
Normal body weight and habitus, BMI less than or equal to 30
Non-smoker
American Society of Anesthesiologists (ASA) physical status classification P1

Exclusion criteria

Cardiovascular: myocardial infarction, coronary artery disease, peripheral vascular disease, arrhythmia, congestive heart failure, valvular disease, hypertension
Respiratory: bronchitis, chronic obstructive pulmonary disease, smoking, shortness of breath
Hepatic: hepatitis, jaundice, ascites
Neurologic: seizure, stroke, positive neurologic findings on neurologic examination, multiple sclerosis, Meniere's disease, Parkinson's disease, neuropathy, peripheral stenosis
Gastrointestinal: esophageal reflux, hiatal hernia, ulcer
Endocrine: diabetes, thyroid disease
Renal: acute or chronic severe renal insufficiency
Hematologic: blood dyscrasias, anemia, coagulopathies, on anticoagulant therapy
Musculoskeletal: prior surgery or trauma to head neck or face, arthritis, personal or family history of malignant hyperthermia
Psychiatric: history or treatment for an active psychiatric problem, depression
Reproductive: pregnancy, breast-feeding
Medications: regular use of prescription and non-prescription medications expected to affect CNS function, St. John's Wort
Allergies: labetalol, ondansetron, glycopyrrolate, ketamine, midazolam