EEG Studies of Sevoflurane-Induced General Anesthesia

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Mass General Brigham

Status and phase

Completed
Phase 2

Conditions

Anesthesia

Treatments

Drug: Ketamine
Drug: Sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT03503578
2014P000111

Details and patient eligibility

About

The investigators are performing this research study to find out how and where the anesthetic drugs sevoflurane and ketamine act in the brain. Sevoflurane and ketamine are anesthetics (a drug or agent used to decrease or eliminate the feeling of pain by causing unconsciousness). The investigators will study the brain using a machine that records the brain's electrical activity, called an electroencephalogram (EEG).

Full description

During this research study, participants will receive sevoflurane, and sevoflurane and ketamine together, at a high enough dose to induce general anesthesia (make study participants "fall asleep"). During one visit participants will receive only sevoflurane; during another visit participants will be given both sevoflurane and ketamine together. The investigators will record EEG the entire time. The investigators will also ask some questions related to pain and cognitive function.

Enrollment

12 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Between the ages of 18 and 50
  • Normal body weight and habitus, BMI ≤ 30
  • Non-smoker
  • American Society of Anesthesiologists (ASA) physical status classification P1

Exclusion criteria

  • Chronic health conditions

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

12 participants in 1 patient group

EEG Dynamics
Experimental group
Description:
EEG data will be collected on patients receiving sevoflurane, and sevoflurane and ketamine together.
Treatment:
Drug: Sevoflurane
Drug: Ketamine

Trial documents
1

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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