Effect Alveolar Recruitment Manoeuver on Stroke Volume a Randomized Study (hemorecrut-2)

Caen University Hospital

Status: Unknown

Conditions: Alveolar Recruitment Manoeuver; Anesthesia

Treatments: Procedure: alveolar recruitment manoeuver

Study type: Interventional

Funder types: Other

Identifiers

NCT04802421

CHU Caen Normandie 19-024

Details and patient eligibility

About

Objective: to compare the effect of alveolar recruitment manouver through stepwise increase and decrease in airway pressure or sustained 30 secondes 30 cmH2O continuous positive airway pressure on cardiac stroke volume estimated by oesophageal doppler in preload independent anesthetized patients scheduled for surgery.

Full description

Following anesthesia and preload optimisation guided by cardiac stroke volume, patients will be randomised to one alveolr recruitment manoeuver :

• stepwise increase and decrease in positive airway pressure
• sustained 30 secondes 30 cmH2O continuous positive airway pressure The primary objective is the change in cardiac stroke volume.

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients scheduled for major surgery requiring hemodynamic monitoring
• written signed informed consent

Exclusion criteria

• pregnancy
• non sinusal heart rate
• known cardiac right ventricular failure or arterial pulmonary hypertension
• pneumothorax
• known pulmonary emphysema

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

CPAP30

Active Comparator group

Description:

a 30 secondes 30 cmH2O continuous positive airway pressure applied after the orotracheal intubation will be checked and secured following induction of general anesthesia

Treatment:

Procedure: alveolar recruitment manoeuver

STEP30

Active Comparator group

Description:

a stepwise increase (+5 cmH2O) in postivie airway pressure from +5 cmH2O to +30 cmH2O and decrease (-5 cmH2O) from +30 cmH2O to +5 cmH2O applied after the orotracheal intubation will be checked and secured following induction of general anesthesia

Treatment:

Procedure: alveolar recruitment manoeuver