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Effect Inverse Ratio Ventilation on Arterial Oxygenation and Respiratory Mechanics During lapaLAR

G

Gachon University Gil Medical Center

Status

Completed

Conditions

Colorectal Neoplasms

Treatments

Other: inverse IE

Study type

Interventional

Funder types

Other

Identifiers

NCT01897584
GBIRB2013-127 (Registry Identifier)

Details and patient eligibility

About

Changes of inspiration: expiration ration from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics

Full description

Inverse ratio ventilation already known as effective to improve the oxygenation and respiratory mechanics in the ARDS patients. Recently, there were report of decrease in airway pressure and improve in respiratory compliance during inverse ration ventilation undergoing one lung ventilation. We hypothesized that changes of inspiration and expiration ratio from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics in the patients who undergoing laparoscopic low anterior resection. However, prolonged inspiratory time might compromise cerebral perfusion pressure due to an elevation in central venous pressure and concomitant reductions in mean arterial pressure.

Enrollment

30 patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • colorectal cancer

Exclusion criteria

  • obesity (BMI>35), uncontrolled hypertension, coronary artery disease, uncompensated cardiovascular disease, current respiratory disease, open procedure

Trial design

Primary purpose

Prevention

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

30 participants in 1 patient group

Inverse IE
Experimental group
Description:
in only one group, inspiration to expiration ratio 1:2 to 1:1 will be applied during pneumoperitoneum
Treatment:
Other: inverse IE

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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