Effect of a Butyrate Enema on the Systemic Concentration of Short Chain Fatty Acids

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: SCFA Metabolism

Treatments: Dietary Supplement: NaCl; Dietary Supplement: Sodium butyrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02271802

METC 08-2-006

Details and patient eligibility

About

In this placebo-controlled randomized parallel study the effects of a butyrate enema on plasma short-chain fatty acids (SCFA) concentrations and fluxes from portal drained viscera, liver and the splanchnic area are investigated

Full description

Patients undergoing upper abdominal surgery are included. During surgery they receive a butyrate enema or placebo enema. Before and after rectal administration, plasma samples are taken from several veins and arteries to analyse SCFA concentrations and fluxes from portal drained viscera, liver and the splanchnic area.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing open liver resection or pancreaticoduodenectomy

Exclusion criteria

• known parenchymal liver disease
• presence of ileostomy or colostomy
• patients with inflammatory bowel disease
• antibiotics, prebiotics or probiotics 2 months prior to surgery

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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12 participants in 2 patient groups, including a placebo group

Butyrate

Experimental group

Description:

Enema containing sodium butyrate

Treatment:

Dietary Supplement: Sodium butyrate

Placebo

Placebo Comparator group

Description:

Enema containing NaCl

Treatment:

Dietary Supplement: NaCl