Effect of a Casein and Gluten Free Diet in Mexican Children With Autism Spectrum Disorder

University of Guadalajara

Status

Enrolling

Conditions

Autism Spectrum Disorder

Treatments

Other: Gluten free and casein free diet

Study type

Interventional

Funder types

Other

Identifiers

NCT06556290

CI- 01624

Details and patient eligibility

About

Assess the effect of a casein-free and gluten-free diet on gastrointestinal symptoms, clinical variables, and the composition of the intestinal microbiota in Mexican children with autism spectrum disorder.

Full description

The objective of this quasi-experimental pre-post study with time series is to evaluate the effect of a casein-free and gluten-free diet on gastrointestinal symptoms, clinical variables, and the composition of the intestinal microbiota in Mexican children with autism spectrum disorder. The main question it aims to answer is:

Does a casein free and gluten free diet promote a reduction in gastrointestinal symptoms, an improvement in clinical variables, and a state of eubiosis in the composition of the intestinal microbiota in Mexican children with autism spectrum disorder?

Participants will undergo:

An intervention of a casein-free and gluten-free diet for 3 months. Sample collection before and after the nutritional intervention. Clinical evaluations.

Enrollment

20 estimated patients

Sex

All

Ages

4 to 10 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Children between 4-10 years old diagnosed with autism spectrum disorder using the criteria established in the ADOS scale and the CARS.

Exclusion criteria

Children who have received:

Antibiotics
Antimycotics
Probiotic supplements
Prebiotic supplements
Any medication that may alter the microbial composition of the patient, minimum one month prior to sampling.
Children on a strict dietary regimen other than a casein-free and gluten-free diet.
Children with celiac disease or who present any gluten-related disorder.
Children with allergy to dairy products.