Effect of a Lipidic and Proteic Controlled Diet on Parkinson's Disease

U

University of Padova

Status

Unknown

Conditions

Parkinson Disease

Treatments

Other: Ketogenic diet

Study type

Interventional

Funder types

Other

Identifiers

NCT02687698
3575/AO/15

Details and patient eligibility

About

Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of Parkinson's disease. The aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in patients with Parkinson's disease.

Full description

Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of Parkinson's disease. The aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in Parkinson's disease patients.

Enrollment

36 estimated patients

Sex

All

Ages

18 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients with a diagnosis of Parkinson's disease, treated with L-Dopa or other dopaminergic drugs.
  • Mini Mental State Examination (MMSE) >24.
  • Activities of Daily Living >3.

Exclusion criteria

  • Mini nutritional assessment <17; BMI <18, hypoalbuminemia or lymphopenia.
  • acute or chronic liver diseases;
  • renal function impairment (Clearance creatinine <30ml/min);
  • cancer;
  • acute inflammatory diseases;
  • thyroid diseases;
  • diabetes mellitus;
  • dysphagia;
  • dementia;
  • dyslipidemia;
  • history of recent cardiovascular or cerebrovascular events;
  • psychiatric diseases;
  • iatrogen parkinsonism.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

36 participants in 2 patient groups

Ketogenic diet
Experimental group
Description:
Patients will be suggested to follow a ketogenic diet for 8 weeks.
Treatment:
Other: Ketogenic diet
Control
No Intervention group
Description:
Usual diet.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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