Effect of a Low-glycemic-load and Milk-free Diet on Acne Severity

Parc Taulí Hospital Universitari

Status: Unknown

Conditions: Acne Vulgaris

Treatments: Other: Low-glycemic-load and milk-free diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01969175

HPT 2013-059

Details and patient eligibility

About

The objective of this study is to assess the effect of a low-glycemic-load and milk-free diet on acne severity.

IGF-1 and a phosphorylated product of the mTORC pathway (p70S6K) will be assessed in both groups to explore the mTORC signaling pathway, which is thought to be related to clinical improvement in previous studies.

Enrollment: 60 estimated patients

Sex: All

Ages: 14 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mild, moderate or severe acne (GAGS score 15-44)
• Age: 14-20 years old
• Presence of acne for at least 2 months

Exclusion criteria

• Diabetes
• Polycystic ovary syndrome
• Use of hormonal contraceptives
• Previous use of oral retinoids
• Use of oral antibiotics or topical antibacterial or retinoid agents in the last 2 months
• Use of medications known to cause or exacerbate acne including lithium, oral or injected retinoids, some anticonvulsant drugs, medications containing iodides or bromides
• Drug or alcohol abuse.
• Active smokers
• Anticipated difficulty attending visits or fear of blood draws

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups, including a placebo group

Intervention Diet

Experimental group

Treatment:

Other: Low-glycemic-load and milk-free diet

Control

Placebo Comparator group