Effect of a Mixed Macronutritional Meal With Medium Chain Triglycerides on the Oxidation of Postprandial Macronutrients

University of Granada (UGR)

Status: Unknown

Conditions: Metabolic Syndrome

Treatments: Dietary Supplement: Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides; Dietary Supplement: Mixed meal with medium chain triglycerides

Study type: Interventional

Funder types: Other

Identifiers

NCT04321018

nº 1102/CEIH/2020

Details and patient eligibility

About

The main aim of this study is to determine the effect of the addition of medium chain triglycerides to a mixed macro nutritional meal on postprandial macronutrients oxidation (i.e. fat oxidation, carbohydrate oxidation, change in respiratory quotient, peak respiratory quotient, etc.).

Full description

A mixed meal characterized by a high quantity of carbohydrates could develop an increment in the postprandial carbohydrate oxidation. Medium chain triglycerides could be absorbed and metabolized immediately. It is plausible that its addition to a mixed meal unchains the decrement in the carbohydrate oxidation and increment in fat oxidation. If this hypothesis it is correct, its lower postprandial carbohydrate oxidation could develop a higher postprandial exposure to hyperglycemia, being of clinical interest.

20 young adults will be randomized into two conditions (experimental and control conditions) with 7 days of separation between conditions. Each evaluation day will conform to the following tests:

1. Basal metabolic rate assessment through indirect calorimetry.
2. Intake of the corresponding mixed meal (experimental or control)
3. Postprandial nutrient oxidation and energy expenditure through indirect calorimetry
4. Blood samples assessment in 9 time points during the evaluation day.
5. Post-prandial sensations related to appetite in 11 time points during the evaluation day

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy male or female
• Ages 18-30 years
• BMI: 18-27.5 kg/m2
• Stable weight over the last 3 months (body weight changes<35kg)
• Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.

Exclusion criteria

• History of cardiovascular disease
• Diabetes or hypertension
• Pregnant, planning to become pregnant, or breastfeeding
• Have been treated previously or during the study period with prescription drugs: antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
• Hematological pathology
• Have had a blood transfusion or severe blood loss within the last 3 months
• Allergy/intolerance to milk proteins, fish, soy, and/or any ingredient of the mixed meal
• Any non-controlled medical condition which could influence results or could be worsened by the participation in the study
• Claustrophobia
• Needle phobia
• Are deemed unsuitable by the investigator for any other reason, that prevent data collection.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Meal with medium chain triglycerdies first

Experimental group

Description:

Arm 1: participants randomized to receive the mixed meal with medium chain triglycerides first.

Treatment:

Dietary Supplement: Mixed meal with medium chain triglycerides

Dietary Supplement: Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides

Meal with medium chain triglycerdies second

Active Comparator group

Description:

Arm 2: participants randomized to receive the mixed meal without medium chain triglycerides first.te

Treatment:

Dietary Supplement: Mixed meal with medium chain triglycerides

Dietary Supplement: Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides