Effect of a Nasal Bolus Allergen Challenge on Inflammatory Markers

Pfizer

Status and phase: Completed; Phase 1

Conditions: Seasonal Allergic Rhinitis

Treatments: Procedure: Intra-nasal allergen challenge with Phleum pratense.; Procedure: Collection of nasal effluent using filter paper.; Procedure: Measurement of nasal congestion using acoustic rhinometry.

Study type: Interventional

Funder types: Industry

Identifiers

NCT00483353

A9011058

Details and patient eligibility

About

The current study will investigate nasal inflammatory markers obtained by filter paper collection techniques, in subjects with allergic rhinitis, determining the most appropriate time points and handling conditions, prior to running a larger study with subjects with allergic rhinitis.

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female subjects with allergic rhinitis, that have a positive skin prick response to Phleum pratense.

Exclusion criteria

• Subjects with a history of asthma. Current smokers, or recent ex-smokers and subjects that have had a respiratory tract infection in the previous 4 weeks.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)