Effect of a Novel Protein Ingredient Combined With Oral Nutritional Supplement on Appetite in Older Adults

University College Dublin

Status

Active, not recruiting

Conditions

Aging

Undernutrition

Appetite Loss

Treatments

Dietary Supplement: Oral Nutritional Supplement

Dietary Supplement: Oral Nutritional Supplement + Whey Protein Hydrolysate

Dietary Supplement: Whey Protein Hydrolysate + still water

Study type

Interventional

Funder types

Other

Identifiers

NCT06478147

LS-22-64-Horner#2

Details and patient eligibility

About

Reduced appetite can occur with ageing and is linked to a higher risk of undernutrition, poorer physical function and becoming frail. Strategies to increase appetite are needed to improve healthy ageing. This study follows on from previous work which has found a novel ingredient in whey protein (derived from whole milk) that may help to increase appetite and energy intake. This study will compare the effects of the ingredient added to an oral nutritional supplement (ONS) versus the ONS alone versus the ingredient dissolved in water on appetite in older adults. By studying this nutrition supplement in older adults, this will help to provide greater information on possible nutrition strategies to improve healthy ageing.

Enrollment

17 patients

Sex

All

Ages

60 to 120 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Community-dwelling,
Age 60+ years
Poor appetite (Simplified Nutritional Appetite Questionnaire (SNAQ) score </=14, answer a, b or c to Q.1 on SNAQ or answer b, c, or d to CES-D question regarding poor appetite in the past week)
BMI 20-25kg/m2

Exclusion criteria

Current medical condition or medication known to impact appetite or energy intake
Other medical condition that would impact study participation and outcomes, as judged by the study investigator.
Heavy smoker (>10/day)
Inability to come to study centre
Currently participating in another intervention study
Lacking informed consent
Allergic to or unwilling to consume any of the study test foods
Loss of taste or smell associated with COVID-19
Unable to walk across a room

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

17 participants in 3 patient groups, including a placebo group

Oral Nutritional Supplement

Placebo Comparator group

Description:

125 mL of commercially available of Oral Nutritional Supplement, a liquid food product containing vitamins, minerals, protein, fats and carbohydrates. 125 mL of product provides 37.0 g of carbohydrates, 11.6 g of fats, 12.0 g of proteins, vitamins and minerals.

Treatment:

Dietary Supplement: Oral Nutritional Supplement

Oral Nutritional Supplement + Whey Protein Hydrolysate

Experimental group

Description:

2,2 grams of whey protein hydrolysate dissolved in 125 mL of commercially available of Oral Nutritional Supplement

Treatment:

Dietary Supplement: Oral Nutritional Supplement + Whey Protein Hydrolysate

Whey Protein Hydrolysate

Active Comparator group

Description:

2,2 grams of whey protein hydrolysate dissolved in 125 mL of water