Effect of a Novel Protein Supplement on Appetite in Older Adults

University College Dublin

Status: Completed

Conditions: Aging; Appetite Loss

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Whey Protein Concentrate; Dietary Supplement: Whey hydrolysate

Study type: Interventional

Funder types: Other

Identifiers

NCT05871060

TC201800025 (Other Grant/Funding Number)

LS-22-64-Horner

Details and patient eligibility

About

An acute randomized crossover trial comparing the effects of the whey hydrolysate, whey protein concentrate and placebo (still flavored water) on appetite and energy intake in older adults. Both low-dose whey-derived treatment and placebo will be administered 30 minutes prior to breakfast and lunch meals. Moreover, ghrelin secretion and activity will be monitored throughout the morning until the lunch time. Appetite will be assessed through visual analogue scale questionnaires.

Enrollment: 14 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Community-dwelling,
• Age 60+ years
• Poor appetite (Simplified Nutritional Appetite Questionnaire (SNAQ) score </=14, answer a, b or c to Q.1 on SNAQ or answer b, c, or d to CES-D question regarding poor appetite in the past week)
• BMI 20-25kg/m2

Exclusion criteria

1. Current medical condition or medication known to impact appetite or energy intake
2. Other medical condition that would impact study participation and outcomes, as judged by the study investigator.
3. Heavy smoker (>10/day)
4. Inability to come to study centre
5. Currently participating in another intervention study
6. Lacking informed consent
7. Allergic to or unwilling to consume any of the study test foods
8. Loss of taste or smell associated with COVID-19
9. Unable to walk across a room

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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14 participants in 3 patient groups, including a placebo group

whey concentrate supplement

Active Comparator group

Description:

2,2 grams of whey concentrate dissolved in 100 mL of water

Treatment:

Dietary Supplement: Whey Protein Concentrate

whey hydrolysate supplement

Experimental group

Description:

2,2 grams of whey hydrolysate dissolved in 100 mL of water

Treatment:

Dietary Supplement: Whey hydrolysate

still flavoured water

Placebo Comparator group

Description:

100 mL of vanilla-flavoured water

Treatment:

Dietary Supplement: Placebo