Effect of a Single Nights' Wake Followed by Bright Light Therapy for Severe Depression

Sahlgrenska University Hospital

Status: Terminated

Conditions: Depression

Treatments: Drug: Treatment as usual - medicine; Other: Informative meeting; Behavioral: Single night's wake therapy; Other: Treatment as usual - inpatient care; Device: Bright light

Study type: Interventional

Funder types: Other

Identifiers

NCT02503124

CB001

Details and patient eligibility

About

A randomized controlled trial comparing wake therapy (single night) followed by bright light therapy to treatment as usual.

Enrollment: 32 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Depressive episode requiring admission to a psychiatric hospital (including unipolar and bipolar depression).

Exclusion criteria

• Psychotic symptoms/agitation
• Compulsory admission
• Confusion
• Active substance use disorder
• Eye disease preventing bright light therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

32 participants in 2 patient groups

Chronobiological intervention

Experimental group

Description:

Single night's wake therapy followed by bright light therapy for a week as add-on treatment to treatment as usual.

Treatment:

Other: Treatment as usual - inpatient care

Drug: Treatment as usual - medicine

Device: Bright light

Behavioral: Single night's wake therapy

Control

Active Comparator group

Description:

Treatment as usual including a private educational meeting in sleep hygiene.

Treatment:

Other: Treatment as usual - inpatient care

Drug: Treatment as usual - medicine

Other: Informative meeting