Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents

University Hospital Basel

Status and phase: Completed; Phase 1

Conditions: Endocrine System Diseases

Treatments: Dietary Supplement: test meal (500 kcal)

Study type: Interventional

Funder types: Other

Identifiers

NCT02020395

GI peptides obese adolescents

Details and patient eligibility

About

The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.

Full description

The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.

Enrollment: 30 patients

Sex: All

Ages: 11 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• caucasian youth
• pubertal Tanner stage x, y, or z

Exclusion criteria

• fasting plasma glucose > 7.0 mmol/L
• significant illness
• taking medications

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups, including a placebo group

Test meal (500 kcal)_normal weight

Placebo Comparator group

Description:

ham sandwich chocolate cream orange juice

Treatment:

Dietary Supplement: test meal (500 kcal)

Dietary Supplement: test meal (500 kcal)

Test meal (500 kcal)_obese weight

Active Comparator group

Description:

ham sandwich chocolate cream orange juice

Treatment:

Dietary Supplement: test meal (500 kcal)

Dietary Supplement: test meal (500 kcal)