Effect of a Third COVID-19 Booster Among Health Care Workers

HKSH Medical Group

Status: Completed

Conditions: COVID-19 Vaccines

Treatments: Biological: Third COVID-19 booster

Study type: Observational

Funder types: Industry

Identifiers

NCT05373459

Third COVID-19 booster

Details and patient eligibility

About

A new wave of COVID-19 infections, mainly caused by the Omicron/ Delta variant, has been sweeping the globe since the start of 2022. In response, the administration of a third dose of COVID-19 vaccine was considered to address potential waning immunity over time and reduced effectiveness against the Omicron/ Delta variant. The pandemic also resulted in many infections among health care workers (HCWs) and their households. In this study, a retrospective analysis would perform on risk of COVID-19 infection and their outcome in relation to their COVID-19 vaccination history by using the data repository from one of the Hong Kong private hospitals.

HCWs were required to submit a standardized online self-declaration form for report of 1) demographic of the HCWs, 2) symptoms related history and 3) COVID-19 exposure history once they were COVID-19 confirmed by rapid antigen test against COVID-19 and/or polymerase chain reaction (PCR) test for COVID-19. Subsequent follow up such as contact tracing, COVID-19 PCR testing results of these HCWs and status of return to work were captured by the infection control team in a systematic manner.

Enrollment: 3,167 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All full time staff members of the private hospital

Exclusion criteria

• History of COVID-19 before 2022

Trial design

3,167 participants in 2 patient groups

Health care workers without third COVID-19 booster

Description:

Health care workers received less than 3 doses of COVID-19 vaccine

HCWs with third COVID-19 booster

Description:

Health care workers received at least 3 doses of COVID-19 vaccine

Treatment:

Biological: Third COVID-19 booster